新建解释器
Tools -> Build System -> New Build System…

{
    "shell_cmd": "python -u \"$file\"",
    "file_regex": "^[ ]*File \"(...*?)\", line ([0-9]*)",
    "selector": "source.python",

    "env": {"PYTHONIOENCODING": "utf-8"},

    "variants":
    [
        {
            "name": "Syntax Check",
            "shell_cmd": "python -m py_compile \"\"",
        }
    ]
}

备注：python修改为具体解释器的路径

保存为：**.sublime-build
指定解释器：Tools -> Build System -> **
运行：Ctrl+B

修改解释器
preference -> browse packages -> **.sublime-build

windows

{

    "cmd": ["D:/Program Files/py3/Scripts/python.exe","-u","$file"],

    "file_regex": "^[ ]*File \"(...*?)\", line ([0-9]*)",

    "selector": "source.python",

    "encoding": "utf-8",

}

保存路径一般如下：

windows：

C:\Users\psy\AppData\Roaming\Sublime Text 3\Packages\User

mac:
/Users/qmp/Library/Application Support/Sublime Text 3/Packages/User